Aripiprazole for Borderline Personality Disorder: A Promising Approach

Caden Harrington - 30 Apr, 2023

Introduction to Aripiprazole for Borderline Personality Disorder

Borderline Personality Disorder (BPD) is a mental health condition that affects millions of people worldwide. It can cause extreme mood swings, unstable relationships, and impulsive behaviors, making it difficult for those who suffer from it to lead a normal life. In recent years, aripiprazole has emerged as a promising treatment option for BPD. In this article, we'll explore the potential benefits of using aripiprazole to manage the symptoms of BPD and improve the quality of life for those who struggle with this disorder.

Understanding Borderline Personality Disorder

Before we delve into the use of aripiprazole for BPD, it's important to understand the nature of this complex mental health condition. BPD is characterized by a pervasive pattern of instability in interpersonal relationships, self-image, and emotions. People with BPD often experience intense emotional episodes, which can lead to impulsive and self-destructive behaviors. Additionally, they may have difficulty forming and maintaining stable relationships due to their intense fear of abandonment and rejection.


These symptoms often emerge during adolescence or early adulthood and can persist throughout one's life. The exact cause of BPD is still unknown, but it is believed to be a combination of genetic, environmental, and neurobiological factors. Treatment for BPD typically involves a combination of therapy, medication, and lifestyle changes to help manage symptoms and improve overall functioning.

Aripiprazole: A Brief Overview

Aripiprazole, also known by its brand name Abilify, is an atypical antipsychotic medication that was initially approved by the Food and Drug Administration (FDA) in 2002 for the treatment of schizophrenia. Since then, its uses have expanded to include the management of bipolar disorder, major depressive disorder, and irritability associated with autism. Aripiprazole works by modulating the activity of dopamine and serotonin in the brain, which are neurotransmitters that play a key role in mood regulation and emotional processing.


Recent studies have suggested that aripiprazole may also be an effective treatment for BPD, making it an attractive option for those who have not found relief from other medications or therapy alone.

Aripiprazole's Effectiveness in Managing BPD Symptoms

Several clinical trials and research studies have examined the effectiveness of aripiprazole in reducing the severity of BPD symptoms. Most of these studies have shown positive results, with participants experiencing significant improvements in their emotional regulation, impulsivity, and interpersonal functioning. One study, for example, found that aripiprazole reduced the intensity of mood swings and emotional outbursts in participants with BPD, leading to a decrease in self-harming behaviors and suicidal ideation.


While more research is needed to fully understand the mechanisms by which aripiprazole affects BPD symptoms, these preliminary findings are encouraging and suggest that aripiprazole could be a promising treatment option for those living with this disorder.

Benefits of Aripiprazole for BPD

There are several potential benefits of using aripiprazole to manage BPD symptoms. Some of these benefits include:

Improved emotional regulation

One of the key challenges faced by people with BPD is the inability to regulate their emotions effectively. Aripiprazole has been shown to help stabilize mood and reduce emotional intensity, making it easier for individuals with BPD to manage their emotions and reduce the frequency of emotional outbursts.

Decreased impulsivity

Impulsive behaviors, such as reckless driving, binge eating, or self-harm, are common among those with BPD. Aripiprazole has been shown to help reduce impulsivity and improve decision-making, which can lead to a decrease in these potentially harmful behaviors.

Improved interpersonal functioning

Individuals with BPD often struggle with forming and maintaining stable relationships due to their intense fear of abandonment and rejection. Aripiprazole has been shown to improve interpersonal functioning by reducing emotional volatility and increasing empathy, which can lead to more satisfying and stable relationships.

Potential Side Effects of Aripiprazole

As with any medication, aripiprazole can cause side effects in some individuals. Common side effects of aripiprazole include dizziness, drowsiness, weight gain, and nausea. In rare cases, aripiprazole may cause more serious side effects such as tardive dyskinesia (involuntary muscle movements), neuroleptic malignant syndrome (a severe neurological reaction), or increased risk of suicidal thoughts and behaviors in young adults.


If you are considering using aripiprazole for BPD, it's important to discuss the potential risks and benefits with your healthcare provider in order to make an informed decision about your treatment options.

Conclusion: A Promising Approach for BPD Treatment

While more research is needed to fully understand the potential benefits and risks of using aripiprazole for BPD, the existing evidence suggests that it could be a promising treatment option for those struggling with this complex mental health condition. By helping to stabilize mood, reduce impulsivity, and improve interpersonal functioning, aripiprazole may offer hope for a better quality of life for individuals living with BPD.


If you or someone you know is struggling with BPD, speak with a healthcare professional about incorporating aripiprazole into your treatment plan. Together, you can work to find the most effective strategies to manage your symptoms and improve your overall well-being.

Comments(14)

Chris Bellante

Chris Bellante

May 2, 2023 at 00:55

Aripiprazole ain't a magic bullet but it's the closest thing we got to quiet the storm inside. Dopamine modulation? Yeah that's the ticket. No more impulsive rage spirals, no more self-harm urges. It's not perfect but it's a lifeline.

Nicole Manlapaz

Nicole Manlapaz

May 2, 2023 at 05:27

I've seen this work firsthand. My sister was in and out of hospitals for years. After starting aripiprazole? She started cooking again. Started calling people back. Took up painting. It didn't fix everything but it gave her space to heal. 🙏

JOANNA WHITE

JOANNA WHITE

May 2, 2023 at 22:19

I'm a nurse in psych. We've had 3 patients on aripiprazole for BPD in the last 6 months. Two showed dramatic improvement in emotional regulation. One had weight gain so bad she dropped out. It's not one-size-fits-all but when it clicks? It's beautiful.

Cameron Perry

Cameron Perry

May 4, 2023 at 14:57

Wait so it's not just for psychosis? I thought it was just for schizophrenia. So it's like... balancing neurotransmitters without knocking you out? That's wild. Any long-term data?

Jill Amanno

Jill Amanno

May 4, 2023 at 17:54

You're all missing the point. This isn't about pharmacology. It's about control. Society wants us medicated so we stop screaming into the void. Aripiprazole doesn't cure BPD-it just makes the scream quieter. And that's not healing. That's suppression.

Kelley Akers

Kelley Akers

May 6, 2023 at 06:33

I'm sorry but this is just another example of Big Pharma pushing pills instead of real therapy. You don't fix trauma with chemistry. You fix it with years of work. This is just a bandaid on a gunshot wound.

Lisa Uhlyarik

Lisa Uhlyarik

May 7, 2023 at 02:33

I read the FDA trial data. The effect size was d=0.38. That's barely clinically significant. And the dropout rate was 42%. This isn't a breakthrough. It's a marketing gimmick wrapped in a white coat.

Alyssa Hammond

Alyssa Hammond

May 7, 2023 at 18:07

I've been on this for 3 years. It made me feel like a zombie. I couldn't cry. Couldn't laugh. My emotions were just... muted. And then I gained 50 pounds. And my therapist said I was 'too compliant.' So I quit. Now I'm back in crisis mode. Thanks for the 'promising approach.'

Taylor Smith

Taylor Smith

May 8, 2023 at 06:29

I'm a grad student in clinical psych. Just wanna say the 2023 meta-analysis in JAMA Psychiatry showed moderate effect sizes for emotional lability and interpersonal sensitivity. Not a cure but a tool. And tools aren't bad if used right.

Tammy Cooper

Tammy Cooper

May 8, 2023 at 13:13

So you're telling me the answer to my 15 years of screaming into the void is a pill that makes me sleepy and hungry? Cool. I'll just go back to cutting. At least that gives me something real.

Mandeep Singh

Mandeep Singh

May 10, 2023 at 12:40

Why are you all talking like this is some miracle drug? In India we have no access to this. We have chai and silence. Maybe the real treatment is community. Not chemistry.

erin orina

erin orina

May 11, 2023 at 17:10

I'm so proud of everyone sharing here. This takes guts. I've been on aripiprazole for 2 years. It didn't fix me but it gave me enough calm to start DBT. You're not broken. You're just trying to survive. 💪❤️

Peggy Cai

Peggy Cai

May 12, 2023 at 22:40

The real issue is we treat symptoms not causes. BPD is a response to abandonment trauma. You don't fix childhood wounds with dopamine antagonists. You fix it with love. And love isn't FDA approved.

Frederick Staal

Frederick Staal

May 14, 2023 at 14:36

I'm a psychiatrist. I've prescribed this to 87 patients. 34% had significant improvement. 22% had akathisia. 11% developed tardive dyskinesia. 17% quit due to weight gain. The rest? Just numb. This isn't treatment. It's chemical sedation disguised as care.

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