When your eye turns red, feels gritty, or starts leaking pus, you’re likely dealing with ophthalmic antibiotics, topical medications designed to kill or stop the growth of bacteria in the eye. Also known as antibiotic eye drops, these are the first line of defense against bacterial conjunctivitis, corneal ulcers, and post-surgical infections. Unlike oral antibiotics, they deliver high doses directly to the infected area—fast, targeted, and with fewer side effects.
Not all ophthalmic antibiotics are the same. Some, like ciprofloxacin, work well against a broad range of bacteria and are often used for more serious infections like corneal ulcers. Others, like tobramycin, are stronger against Gram-negative bugs but may cause stinging. Then there’s erythromycin, a gentler option often prescribed for kids or people with sensitive eyes, though it’s less effective against tougher strains. The choice depends on the infection type, your medical history, and whether you’ve used these drugs before.
Many people assume all antibiotic eye drops work the same—but that’s not true. Some require frequent dosing (every hour), while others last longer. Some cost less than $10 with insurance; others can hit $100 without it. And while most are safe, a few can cause allergic reactions or even damage the cornea if used too long. You don’t need to guess which one to use. The posts below break down real comparisons: how ophthalmic antibiotics like levofloxacin, clindamycin phosphate, and others stack up in real-world use. You’ll find out which ones doctors reach for first, which ones to avoid if you’re allergic to penicillin, and which ones offer the best balance of power, price, and safety.
