Tizanidine and Ciprofloxacin: Why This Drug Combination Can Cause Dangerous Low Blood Pressure and Extreme Drowsiness

Caden Harrington - 14 Nov, 2025

Two common prescriptions - one for muscle spasms, another for a urinary tract infection - might seem harmless on their own. But when taken together, they can send your blood pressure crashing and leave you too drowsy to stand. This isn’t theoretical. It’s happening in clinics right now, even though doctors and pharmacists have known about it for years.

What Happens When Tizanidine Meets Ciprofloxacin

Tizanidine is a muscle relaxant. It works by calming overactive nerves in your spinal cord, helping with back pain, neck stiffness, or spasticity from conditions like multiple sclerosis. Ciprofloxacin is an antibiotic - a fluoroquinolone - used to treat bacterial infections like pneumonia, kidney infections, or sinusitis. On paper, they do different jobs. But inside your body, they collide.

The problem lies in how your liver breaks down tizanidine. About 95% of it is processed by a single enzyme: CYP1A2. Ciprofloxacin doesn’t just touch this enzyme - it shuts it down. Hard. When you take ciprofloxacin, your body can’t clear tizanidine the way it should. Instead of being broken down and flushed out, tizanidine builds up. Studies show levels can spike 10 to 33 times higher than normal.

That’s not a small increase. That’s a medical emergency waiting to happen.

The Real Risks: Low Blood Pressure and Deep Sedation

High tizanidine levels don’t just make you sleepy - they can knock your blood pressure into dangerous territory. Severe hypotension means your systolic pressure drops below 70 mm Hg. At that point, your brain and organs don’t get enough blood. You might feel dizzy, nauseous, or faint. In worst-case scenarios, you pass out, hit your head, or need emergency IV fluids and medications just to stabilize your pressure.

Sedation isn’t mild either. People report being unable to stay awake, slurring speech, or needing hospitalization because they couldn’t wake up. One patient in a WHO pharmacovigilance database reported being found unconscious at home after taking both drugs. He spent three days in the hospital.

These aren’t rare outliers. A study from Vanderbilt University Medical Center, analyzing real patient records, found a 43% higher chance of severe low blood pressure when these two drugs were taken together. That’s not a 5% risk. That’s nearly half again more likely to land you in the ER.

Why This Interaction Is Unique to Tizanidine

Not all muscle relaxants behave like this. Cyclobenzaprine, another common one, is broken down by multiple liver enzymes. If one pathway gets blocked, others can still clear the drug. Tizanidine doesn’t have that safety net. It relies entirely on CYP1A2. That’s why it’s uniquely vulnerable.

This is why experts like Dr. Cecilia Chung and her team at Vanderbilt call this interaction “a perfect storm.” Ciprofloxacin isn’t the only offender - fluvoxamine (an antidepressant), amiodarone (a heart rhythm drug), and even some over-the-counter supplements like St. John’s Wort in certain forms can do the same thing. But ciprofloxacin is one of the most common antibiotics prescribed, especially to older adults with UTIs - the exact group also likely to be on tizanidine for chronic back pain.

Who’s Most at Risk?

You’re at higher risk if:

• You’re over 65
• You’re already taking blood pressure meds (like lisinopril, amlodipine, or hydrochlorothiazide)
• You have kidney or liver problems
• You take more than three other medications

The more conditions you have, the more your body struggles to handle the overload. One study showed patients with high comorbidity scores had the worst reactions - sometimes requiring ICU care just to manage their blood pressure.

What Doctors Should Do - And What They Often Don’t

The FDA and EMA both list this combination as contraindicated. That means it’s officially unsafe. The tizanidine package insert says it outright: “Do not use with CYP1A2 inhibitors like ciprofloxacin.”

Yet, it still happens.

Why? Because doctors aren’t always thinking about drug metabolism. A patient comes in with a bad back and a UTI. The doctor prescribes tizanidine for the pain and ciprofloxacin for the infection. They don’t connect the dots. The pharmacist might miss it too - especially if the prescription comes through electronically without a clear alert.

A 2019 study found that even with formal warnings, this combo was still being prescribed in routine care. That’s not just negligence - it’s a systemic failure in how we train prescribers and design electronic health systems.

What to Do If You’re on Tizanidine and Need an Antibiotic

If you’re taking tizanidine and your doctor says you need an antibiotic, ask this:

1. Is ciprofloxacin absolutely necessary?
2. Are there alternatives that don’t block CYP1A2?

Good options include:

• Amoxicillin (for UTIs, sinus infections)
• Nitrofurantoin (for uncomplicated UTIs)
• Cephalexin (for skin or respiratory infections)

These don’t interfere with tizanidine metabolism. They’re just as effective for most common infections.

If ciprofloxacin is your only option - and your infection is serious - then stop tizanidine entirely during the course of antibiotics and for at least 5 to 7 days after. Tizanidine’s half-life is about 2.5 hours when working normally. But when CYP1A2 is blocked, it lingers. Waiting a full week ensures it’s fully cleared before restarting.

Never adjust your dose on your own. Talk to your doctor or pharmacist. They can help you plan a safe switch.

What to Do If You’ve Already Taken Both

If you accidentally took tizanidine and ciprofloxacin together:

• Do not drive or operate machinery
• Stay seated or lying down - don’t stand up quickly
• Check your blood pressure if you have a home monitor
• Call your doctor or poison control immediately if you feel faint, dizzy, or unusually sleepy

Symptoms usually appear within hours. Don’t wait for them to get worse. Early intervention can prevent a fall, a stroke, or cardiac arrest.

This Interaction Is Preventable - But Only If We Pay Attention

Tizanidine is prescribed millions of times a year in the U.S. Ciprofloxacin is one of the most common antibiotics. They’re both useful drugs. But together, they’re dangerous.

The solution isn’t to stop using either. It’s to change how we prescribe. Electronic systems need smarter alerts. Doctors need better training on metabolic pathways. Patients need to know to ask: “Could this drug make my other meds dangerous?”

If you’re on tizanidine, keep a list of all your medications. Bring it to every appointment. Ask your pharmacist to review it every time you get a new prescription. That one habit could save your life.

Final Takeaway

This isn’t a “maybe” risk. It’s a confirmed, documented, life-threatening interaction. The data is clear. The warnings are loud. Yet, people still get hurt because we assume medications are safe unless proven otherwise. That’s backwards. We should assume interactions are possible - until proven safe.

If you’re taking tizanidine, avoid ciprofloxacin. Period. And if your doctor suggests it, push back. Ask for an alternative. Your blood pressure - and your safety - depend on it.

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